While it is stated that the disease existed in North Carolina prior
to 1776, the first published statement was by Dr. Daniel Drake, a distin-
guished physician of Ohio, 2 in 1810, who gave the symptoms in some
detail. These symptoms included lassitude, pains in the legs, loss of
appetite, obstinate constipation, vomiting, and a breath " peculiarly
disgusting and even loathsome." He stated that the disease affected
both sexes and all ages, and sometimes continued for months, and that
patients after recovery are liable to recurrences. He said that it
occurred in " aguish " situations, and that since its appearance inter-
mittent diseases declined. (It seems possible that the diagnosis of
trembles or milk sickness as distinct from malarial disease may have
resulted in an apparent diminution of " intermittent diseases.")
strangely, Wikipedia reference for Dr. Daniel Drake doesnt mention the milk sickness study.
“The honest man, tho' e'er sae poor,
Is king o' men for a' that” Robert Burns